Question No 1:
A 3-year-old girl diagnosed with ALL developed an urticarial rash on her upper body extremities and experienced mild bronchospasm 30 minutes into the infusion of her day-15 pegaspargase. The infusion was discontinued, and supportive care measures were instituted. Today is day 43, and the patient is due for her next scheduled dose of pegaspargase.Which is the most appropriate course of action in this situation?
A. Substitute six doses of asparaginase Erwinia chrysanthemi for the one dose of pegaspargase.
B. Substitute nine doses of asparaginase Erwinia chrysanthemi for the one dose of pegaspargase.
C. Resume therapy with pegaspargase, but premedicate the dose with acetaminophen, diphenhydramine, and a corticosteroid.
D. Discontinue all further treatment with any form of asparaginase therapy.
Answers: A
